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Mechanism of steroid action in ocular inflammation: Inhibition of prostaglandin production.
Floman N, Zor U. Floman N, et al. Invest Ophthalmol Vis Sci. 1977 Jan;16(1):69-73. Invest Ophthalmol Vis Sci. 1977. PMID: 319076
Indomethacin (100 mug per milliliter) abolished PGE accumulation. The suppressive action of hydrocortisone on PGE release into the incubation medium was prevented by the addition of arachidonic acid (2 mug per milliliter), a substrate for prostaglandin synthesis. By …
Indomethacin (100 mug per milliliter) abolished PGE accumulation. The suppressive action of hydrocortisone on PGE release into the in …
Pharmacological treatment of presbyopia: A systematic review.
Haghpanah N, Alany R. Haghpanah N, et al. Eur J Transl Myol. 2022 Sep 19;32(3):10781. doi: 10.4081/ejtm.2022.10781. Eur J Transl Myol. 2022. PMID: 36121117 Free PMC article.
There are a number of topical pharmacological agents available for treating presbyopia such as FOV Tears and PresbiDrop. They consist of parasympathetic agent and non-steroidal anti-inflammatory drugs (NSAIDs), to contract the ciliary and pupil muscle and restore the accom …
There are a number of topical pharmacological agents available for treating presbyopia such as FOV Tears and PresbiDrop. They consist of par …
The pharmacological basis of anterior segment therapy.
Vale J. Vale J. Ophthalmic Physiol Opt. 1998 Mar;18(2):91-6. Ophthalmic Physiol Opt. 1998. PMID: 9692027 Review.
Inflammation is a complex, multicomponent, protective response involving the synthesis, release and actions of many chemical mediators, including prostaglandins which are synthesised from cell membrane components. ...Both the non-steroidal anti-inflamm …
Inflammation is a complex, multicomponent, protective response involving the synthesis, release and actions of many chemical m …
Mapracorat, a selective glucocorticoid receptor agonist, upregulates RelB, an anti-inflammatory nuclear factor-kappaB protein, in human ocular cells.
Spinelli SL, Xi X, McMillan DH, Woeller CF, Richardson ME, Cavet ME, Zhang JZ, Feldon SE, Phipps RP. Spinelli SL, et al. Exp Eye Res. 2014 Oct;127:290-8. doi: 10.1016/j.exer.2014.07.013. Exp Eye Res. 2014. PMID: 25245083
The purpose of this study was to investigate a novel SEGRA, mapracorat (BOL-303242-X), and the differences in mapracorat's mechanism of action compared with traditional steroids (i.e. dexamethasone). ...Mapracorat potently inhibits ocular inf …
The purpose of this study was to investigate a novel SEGRA, mapracorat (BOL-303242-X), and the differences in mapracorat's mechanism …